Christopher P. Cardozo

Aug 23, 2023 | biorxiv.org | Mark R. Viggars |Hazel Sutherland |Christopher P. Cardozo |Jonathan Jarvis

AbstractMice are often used in gain or loss of function studies to understand how genes regulate metabolism and adaptation to exercise in skeletal muscle. Once-daily resistance training with electrical nerve stimulation produces hypertrophy of the dorsiflexors in rat, but not in mouse. Using implantable pulse generators, we assessed the acute transcriptional response (1-hour post exercise) after 2, 10 and 20 days of training in free living mice and rats using identical nerve stimulation paradigms.