Mark R. Viggars

Oct 17, 2023 | biorxiv.org | Mark R. Viggars |Ryan Martin |Karyn A. Esser |Hannah E Berko

AbstractObjective: The skeletal muscle circadian clock plays a pivotal role in muscle homeostasis and metabolic flexibility. Recently, this clock mechanism has been linked to both transcriptional and metabolic responses to acute exercise. However, the contribution of the circadian clock mechanism to the molecular and phenotypic adaptations to exercise training have not been defined.

Aug 23, 2023 | biorxiv.org | Mark R. Viggars |Hazel Sutherland |Christopher P. Cardozo |Jonathan Jarvis

AbstractMice are often used in gain or loss of function studies to understand how genes regulate metabolism and adaptation to exercise in skeletal muscle. Once-daily resistance training with electrical nerve stimulation produces hypertrophy of the dorsiflexors in rat, but not in mouse. Using implantable pulse generators, we assessed the acute transcriptional response (1-hour post exercise) after 2, 10 and 20 days of training in free living mice and rats using identical nerve stimulation paradigms.