Christopher Pittenger

May 26, 2023 | frontiersin.org | Christopher Pittenger |Luke Norman |Kate Collins

1. Introduction Obsessive–compulsive disorder (OCD) is a chronic psychiatric disorder characterized by persistent, intrusive thoughts (obsessions) and repetitive, stereotyped behaviors (compulsions). Compulsive behaviors in OCD have been postulated as resulting from alterations in the instrumental behavioral control system, which includes two distinct, parallel systems of behavioral control: goal-directed and habitual (1, 2).

May 26, 2023 | frontiersin.org | Christopher Pittenger |Luke Norman |Kate Collins

1. Introduction Obsessive–compulsive disorder (OCD) is a chronic psychiatric disorder characterized by persistent, intrusive thoughts (obsessions) and repetitive, stereotyped behaviors (compulsions). Compulsive behaviors in OCD have been postulated as resulting from alterations in the instrumental behavioral control system, which includes two distinct, parallel systems of behavioral control: goal-directed and habitual (1, 2).

Apr 10, 2023 | biologicalpsychiatryjournal.com | Cheng Jiang |Christopher Pittenger

Developmental stress has been associated with autism spectrum disorder (ASD), depression, and anxiety disorders. ASD is more common in males, while depression and most anxiety disorders are more common in females. Here, we characterize the influence of early life stress (ELS) on the behavioral pathology relevant to ASD, depression, and anxiety.

Mar 2, 2023 | jbc.org | Jian Xu |Christopher Pittenger

The neuroanatomical organization of the basal ganglia. Hbk Behav. Neurosci. 2010; 20: 3-28Nelson A.B. Kreitzer A.C. Reassessing models of basal ganglia function and dysfunction. Annu. Rev. Neurosci. 2014; 37: 117-135Cui G. Jun S.B. Jin X. Pham M.D. Vogel S.S. Lovinger D.M. et al. Concurrent activation of striatal direct and indirect pathways during action initiation. Nature. 2013; 494: 238-242Hikosaka O. Kim H.F. Yasuda M. Yamamoto S. Basal ganglia circuits for reward value-guided behavior. Annu. Rev. Neurosci.