Kate Collins

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Jul 29, 2024 | bpspubs.onlinelibrary.wiley.com | Srinivas Kamath |UniSa Clinical |Alexander Hunter |Kate Collins

CD68 cluster of differentiation 68 ChREBP carbohydrate regulatory element binding protein F:B Firmicutes:Bacteroidetes LOQ limit of quantification OTU operational taxonomical unit PCoA principal coordinate analysis PUL polysaccharide utilisation loci SCFA short chain fatty acid SREBP-1c sterol-regulatory element binding protein 1c What is already known? Olanzapine induces weight gain by disrupting the gut microbiome.

Jul 19, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractThis study investigates the impact of gut microbiome composition on the bioavailability and biodistribution of lurasidone hydrochloride, an atypical antipsychotic used in treating mental health conditions. The research aims to uncover the relationship between gut metabolome, specifically short-chain fatty acids (SCFAs), and lurasidone absorption through modulation of intestinal pH.

Apr 24, 2024 | yahoo.com | Kate Collins

I used to shop at Trader Joe's daily because it was close to work. However, after changing jobs, I began shopping at Aldi to save some money. I've grown to love Aldi's wide aisles, low prices, and great products. Before I shopped at Trader Joe's, I was never loyal to any one grocery store. Like many shoppers, my store choice was driven primarily by convenience: whichever grocer was closest to me became my go-to. That's why when I worked near Trader Joe's, I stopped there daily.