Kate Collins

2 weeks ago | businessinsider.com | Conz Preti |Kate Collins |Henry Blodget

Soon after my 50th birthday, I became single after a long relationship ended. I moved into an apartment, walked with my dog, and spent the winter in quiet self-reflection. As the days grew longer, I swiped dating apps with two non-negotiables in mind: a narrow geographic boundary and no young children at home. Yet at 52, I became the stepmother to a teenager. His son was the center of everythingI never had children, but my now husband became a parent in his 40s.

1 month ago | businessinsider.com | Lauryn Haas |Kate Collins |Henry Blodget

When I walked into work last year on my birthday, there was an envelope with my name written in cursive on my desk. I was less than three months into a new job and hadn't announced my birthday. Being an introvert, a slight discomfort rose as I opened the envelope. The discomfort dissipated as I read the personalized messages written by my colleagues. I was grateful for the simple gesture; this was the first time I received a birthday card at work.

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Aug 2, 2024 | biorxiv.org | Kate Collins |Srinivas Kamath |Tahlia R. Meola |Anthony Wignall

AbstractAtypical antipsychotics are crucial for the management of schizophrenia and bipolar disorder, yet they exhibit significant pharmacokinetic variability which leads to inconsistent therapeutic responses. This study investigates the hypothesis that gut microbiome composition critically influences the oral bioavailability of lurasidone, a poorly soluble weak base antipsychotic with pH-dependent solubility.

Jul 29, 2024 | bpspubs.onlinelibrary.wiley.com | Srinivas Kamath |UniSa Clinical |Alexander Hunter |Kate Collins

CD68 cluster of differentiation 68 ChREBP carbohydrate regulatory element binding protein F:B Firmicutes:Bacteroidetes LOQ limit of quantification OTU operational taxonomical unit PCoA principal coordinate analysis PUL polysaccharide utilisation loci SCFA short chain fatty acid SREBP-1c sterol-regulatory element binding protein 1c What is already known? Olanzapine induces weight gain by disrupting the gut microbiome.