Chuan Qin

Oct 19, 2024 | mdpi.com | Yan Cao |Fan Ye |Ling Zhang |Chuan Qin

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Oct 27, 2023 | nature.com | Jinrong Fu |Guoping Lu |Iain B McInnes |Chuan Qin |Yufeng Zhou

AbstractCytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-e). We identified IL-37a as a nuclear cytokine for the first time. Compared to IL-37b, IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic shock.