Guoping Lu

Oct 27, 2023 | nature.com | Jinrong Fu |Guoping Lu |Iain B McInnes |Chuan Qin |Yufeng Zhou

AbstractCytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-e). We identified IL-37a as a nuclear cytokine for the first time. Compared to IL-37b, IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic shock.