Chunhua Song

Jul 24, 2024 | journals.plos.org | Xing Guo |Run Zhang |Juan Liu |Chunhua Song

Fig 4 is uploaded incorrectly. Please view Fig 4 here. Fig 4. LEF1 mutants promote cell proliferation of ALL cells. A-B.LEF1 wild-type (LEF1-WT) and its mutants (LEF1-K86E and LEF1-P106L) were expressed in Molt4 (A) and Nalm6 (B) cells. * P<0.05; **P<0.01; ***P<0.001. Reference1. Guo X, Zhang R, Liu J, Li M, Song C, Dovat S, et al. (2015) Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia. PLOS ONE 10(5): e0125429.

May 10, 2023 | frontiersin.org | Quan Chen |Chunhua Song |Alexander D. Barrow |Sjoerd Schetters

IntroductionGliomas are the most common and aggressive primary brain tumors associated with a very poor prognosis, especially glioblastoma (GBM), with a 5-year overall survival rate below 5% (1). Conventional therapeutic strategies for GBM are unsatisfactory. Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 alone have produced a demonstrable therapeutic benefit in several tumor types; however, their efficacy in gliomas has not been satisfactory (2, 3).