Chunying Chen

Jul 23, 2024 | nature.com | Peng Zhang |Mingjing Cao |Andrew J. Chetwynd |Fazel Abdolahpur Monikh |Laura-Jayne Ellis |Katie Reilly | +1 more

AbstractA biomolecular coating, or biocorona, forms on the surface of engineered nanomaterials (ENMs) immediately as they enter biological or environmental systems, defining their biological and environmental identity and influencing their fate and performance. This biomolecular layer includes proteins (the protein corona) and other biomolecules, such as nucleic acids and metabolites.

May 17, 2024 | nature.com | Ye Sun |Ying Hu |Flemming Besenbacher |Chunying Chen

AbstractThe role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in the tumor microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating antibacteria with antitumor treatment, addressing the aggravated immunosuppression and tumor overgrowth induced by TRIM using breast and prostate cancer models.