CIC Neurosciences

Mar 1, 2024 | academic.oup.com | Institut du Cerveau |Département de Neurologie |CIC Neurosciences

This scientific commentary refers to ‘Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease’ by Yu et al. (https://doi.org/10.1093/brain/awad345). Recent genome-wide association studies (GWAS) have identified 90 independent risk variants for idiopathic Parkinson’s disease at 78 loci scattered across the genome.1 Each of these variants individually confers a low risk of developing Parkinson’s disease, rendering the disease polygenic.