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Nov 13, 2024 | 
jamanetwork.com | Hugo Bottemanne |Assistance Publique |Institut du Cerveau |Lucie Joly
How the Paternal Brain Is Wired by Pregnancy Pregnancy and post partum are accompanied by structural and functional brain changes in women that are thought to be important for caregiving.1 Studies have shown that pregnancy in women is associated with extensive gray matter volume reductions during pregnancy.1 Compared with controls, expecting mothers present lower cortical volume across several brain areas, with fewer cortical differences in the early postpartum period.1 Some of these brain...
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Oct 26, 2024 | 
onlinelibrary.wiley.com | Eva H. Brilstra |Floor Jansen |Sara Baldassari |Institut du Cerveau
1 INTRODUCTION Epilepsy surgery is the most effective treatment in epilepsy patients who develop refractory seizures, provided that the epileptogenic zone is focal, well delineated, preferably of presumed structural origin, and outside eloquent areas.1 Genetic malformations of cortical development (MCD), such as mild MCD (mMCD), mMCD with oligodendroglial hyperplasia and epilepsy (MOGHE), focal cortical dysplasia (FCD; especially FCDIIa and FCDIIb subtypes), and hemimegalencephaly (HMEG)...
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Oct 19, 2024 | 
movementdisorders.onlinelibrary.wiley.com | Emmanuel Roze |Institut du Cerveau |AP-HP Paris France
The Ultragenyx@-sponsored phase 3 randomized controlled study evaluating the effect of triheptanoin to treat paroxysmal episodes of movement disorders related to Glut1 deficiency syndrome (Glut1-DS) failed to demonstrate efficacy.1 This was unexpected considering the rationale supporting the use of triheptanoin,2 and the striking results of preliminary investigator-driven open-label studies that showed over 90% reduction of paroxysmal movement disorders in patients with Glut1-DS,3, 4 a...
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Oct 8, 2024 | 
academic.oup.com | Institut du Cerveau |Movement Neurosciences
Spinocerebellar ataxia 27B (SCA27B) is a common autosomal dominant ataxia caused by an intronic GAA•TTC repeat expansion in FGF14. Neuropathological studies have shown that neuronal loss is largely restricted to the cerebellum. Although the repeat locus is highly unstable during intergenerational transmission, it remains unknown whether it exhibits cerebral mosaicism and progressive instability throughout life.
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Sep 23, 2024 | 
movementdisorders.onlinelibrary.wiley.com | Guillaume Cogan |Institut du Cerveau |Christelle Tesson
More than a dozen genes are involved in monogenic forms of Parkinson's disease (PD).1 Their discovery have contributed to our understanding of the biology of PD and highlighted the role of α-synuclein, mitochondrial homeostasis, vesicle trafficking, endolysosomal system, and other pathways in PD.2 However, they explain only less than 10% of PD cases, suggesting that more genes are still to be identified.
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Sep 19, 2024 | 
link.springer.com | Institut du Cerveau
Exploring the glymphatic system across neurological and metabolic diseases might help us to better define the link between obesity and neurological disorders. Recent studies have identified metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through disruption of the glymphatic system. This is a preview of subscription content, to check access. Price excludes VAT (USA) Tax calculation will be finalised during checkout.
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Sep 14, 2024 | 
academic.oup.com | Institut du Cerveau |Emmanuel Mandonnet
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. This content is only available as a PDF. © The Author(s) 2024.
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Sep 14, 2024 | 
academic.oup.com | Institut du Cerveau |Lopez-Persem A
This scientific commentary refers to ‘Default mode network electrophysiological dynamics and causal role in creative thinking’ by Bartoli et al. (https://doi.org/10.1093/brain/awae199). Despite what the term ‘default’ implies, the default mode network (DMN) is now recognized as a key intrinsic functional brain network essential for high-level human cognition.
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Aug 21, 2024 | 
academic.oup.com | Institut du Cerveau |e Marcos Antônio
With the significant shift in the classification, risk stratification, and standards of care for gliomas, we sought to understand how the overall survival of patients with these tumors is impacted by molecular features, clinical metrics, and treatment received. We assembled a cohort of patients with a histopathologically diagnosed glioma from The Cancer Genome Atlas, Project Genomics Evidence Neoplasia Information Exchange, and Dana-Farber Cancer Institute/Brigham and Women’s Hospital.
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Aug 4, 2024 | 
link.springer.com | Institut du Cerveau |Chu Rouen
AbstractPhysical activity combined with virtual reality and exergaming has emerged as a new technique to improve engagement and provide clinical benefit for gait and balance disorders in people with Parkinson’s disease (PD). To investigate the effects of a training protocol using a home-based exergaming system on brain volume and resting-state functional connectivity (rs-FC) in persons with PD.
