Civin Laboratory

Dec 2, 2024 | link.springer.com | Anna Katharina |Civin Laboratory |SUN CITY

AbstractThe formation of amyloid-β (Aβ) aggregates in brain is a neuropathological hallmark of Alzheimer’s disease (AD). However, there is mounting evidence that Aβ also plays a pathogenic role in other types of dementia and that specific post-translational Aβ modifications contribute to its pathogenic profile. The objective of this study was to test the hypothesis that distinct types of dementia are characterized by specific patterns of post-translationally modified Aβ variants.

Jun 27, 2024 | alz-journals.onlinelibrary.wiley.com | Clifford R. Jack |J. Scott Andrews |Thomas G Beach |Civin Laboratory

1 BACKGROUND In 2011, the National Institute on Aging and the Alzheimer's Association (NIA-AA) convened three workgroups that published separate recommendations for the diagnosis and evaluation of Alzheimer's disease (AD) in its preclinical, mild cognitive impairment (MCI), and dementia phases.1-4 In 2012, an NIA-AA workgroup published a consensus document on the neuropathologic diagnosis of AD.5, 6 Several years later, the NIA-AA convened a single workgroup to update 2011 recommendations for...

Aug 11, 2023 | movementdisorders.onlinelibrary.wiley.com | Thomas G Beach |Civin Laboratory |Charles Adler

Financial disclosures relevant to this article: None.