Clifford R. Jack

Jan 16, 2025 | nature.com | Farwa Ali |Michelle M. Mielke |Clifford R. Jack |David S. Knopman |Prashanthi Vemuri |Ronald Petersen | +1 more

AbstractDeclining gait performance is seen in aging individuals, due to neural and systemic factors. Plasma biomarkers provide an accessible way to assess evolving brain changes; non-specific neurodegeneration (NfL, GFAP) or evolving Alzheimer’s disease (Aβ 42/40 ratio, P-Tau181). In a population-based cohort of older adults, we evaluate the hypothesis that plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are associated with worse gait performance.

Nov 6, 2024 | nature.com | Duygu Tosun |Meryl A. Butters |Andrew J. Saykin |Arthur W. Toga |Clifford R. Jack

AbstractThis study was conducted to clarify patterns of cortico-limbic volume abnormalities in late life depression (LLD) relative to non-depressed (ND) adults matched for amyloid β (Aβ) deposition and to evaluate the relationship of volume abnormalities with cognitive performance. Participants included 116 LLD and 226 ND. Classification accuracy of LLD status was estimated using area under the receiver operator characteristic curve.

Jun 27, 2024 | alz-journals.onlinelibrary.wiley.com | Clifford R. Jack |J. Scott Andrews |Thomas G Beach |Civin Laboratory

1 BACKGROUND In 2011, the National Institute on Aging and the Alzheimer's Association (NIA-AA) convened three workgroups that published separate recommendations for the diagnosis and evaluation of Alzheimer's disease (AD) in its preclinical, mild cognitive impairment (MCI), and dementia phases.1-4 In 2012, an NIA-AA workgroup published a consensus document on the neuropathologic diagnosis of AD.5, 6 Several years later, the NIA-AA convened a single workgroup to update 2011 recommendations for...

Jul 10, 2023 | nature.com | Nicole McKay |Brian Gordon |Shaney Flores |Nelly Joseph-Mathurin |Clifford R. Jack |Peter Millar | +19 more

All data described in the current resource manuscript are freely available upon completion of a DIAN-OBS Data Request Form. This request procedure allows DIAN to implement a transparent and inclusive data-sharing practice while maximizing confidentiality and security of our participants’ protected personal information. Every submission is reviewed by the DIAN principal investigator as well as relevant DIAN core leaders (that is, the Imaging Core leader).