Claire Broderick

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SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications

Nov 30, 2024 | nature.com | Joshua Rosenheim |Claire Broderick |Loukas Papargyris |Andrew Kwok |Helen R. Wagstaffe |Emily Conibear | +15 more

AbstractBlood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles.

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