Joshua Rosenheim

Nov 30, 2024 | nature.com | Joshua Rosenheim |Claire Broderick |Loukas Papargyris |Andrew Kwok |Helen R. Wagstaffe |Emily Conibear | +15 more

AbstractBlood transcriptional biomarkers of acute viral infections typically reflect type 1 interferon (IFN) signalling, but it is not known whether there are biological differences in their regulation that can be leveraged for distinct translational applications. We use high frequency sampling in the SARS-CoV-2 human challenge model to show induction of IFN-stimulated gene (ISG) expression with different temporal and cellular profiles.

Mar 30, 2023 | nature.com | Sarah J Buddle |José Afonso Guerra-Assunção |Moradi Marjaneh |Nathaniel Storey |Luis A. Campos |Luís Campos | +21 more

AbstractSince its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods.