Claire Eyers

Apr 24, 2024 | nature.com | Claire Eyers

Understanding the role of pyrophosphorylation requires specific analytical strategies to discriminate it from protein phosphorylation. A custom workflow reveals that nucleolar protein pyrophosphorylation in human cells regulates the transcription of ribosomal DNA.

Jul 12, 2023 | dx.doi.org | Allen Po |Claire Eyers |Young Ah |I. Jonathan

Proteomics, namely analysis of the “entire protein complement expressed by a genome, or by a cell or tissue type” under defined conditions, (1) is an essential means of exploring physiology and the changes that occur, e.g., during stress, infection, or disease. By collating such information, it is possible to explore protein function and evaluate the effects of targeted intervention of a protein or pathway, for example with small molecule inhibitors.