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Jul 18, 2024 | 
msn.com | Claire Hendershot
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Jul 18, 2024 | 
phys.org | Claire Hendershot
Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren't safe.
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Jul 17, 2024 | 
broadinstitute.org | Claire Hendershot
Skip to main content About usThis is Broad Learn about our mission, our values, our history, and partner institutions. People Meet our members, staff scientists, fellows, leadership, and other Broadies. Join Broad Find out how to join the Broad as an employee or associate member. Contact us Find our contact information, directions to our buildings, and directory. Broad@20 Broad turns 20 this year! See how we’re celebrating our 20th anniversary.
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Jun 11, 2024 | 
broadinstitute.org | Claire Hendershot
When Moe Haines first moved from Beirut, Lebanon to the United States for college, his goal was to earn a degree in pharmacy. Haines was the first person in his family to pursue science, and most people he knew with similar interests had chosen a career in medicine. But his first few biology classes in community college exposed him to the possibility of a career in genetics, chemistry, or physics.
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Mar 20, 2024 | 
medicalxpress.com | Claire Hendershot
Researchers have developed statistical tools called polygenic risk scores (PRSs) that can estimate individuals' risk for certain diseases with strong genetic components, such as heart disease or diabetes. However, the data on which PRSs are built is often limited in diversity and scope. As a result, PRSs are less accurate when applied to populations that differ demographically from the PRS training data.
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Mar 19, 2024 | 
broadinstitute.org | Claire Hendershot
A new scoring approach featured in Cell Genomics and developed by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) uses a comprehensive approach to generate more accurate and informative PRSs. Aptly named PRSmix due to its ability to “mix” all previously developed PRSs for a given trait, the approach generates scores that estimate a patient’s genetic disease risk more accurately than PRSs generated from individual studies.
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Mar 11, 2024 | 
medicalxpress.com | Claire Hendershot
Malaria prevalence has decreased drastically over the past two decades, but clinics in West Africa are still full of patients with fevers and symptoms similar to, but not exactly like, malaria. Little is known about the pathogens that cause these infections, and so these "non-malarial febrile illnesses" (NMFI) often fly under the radar of infectious disease surveillance programs because researchers don't know which pathogens to look for.
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Mar 8, 2024 | 
broadinstitute.org | Claire Hendershot
Why did you and your colleagues in Senegal decide to do this study? Siddle: This project was somewhat born out of a sense that there was relatively limited diagnostic testing available. Senegalese clinicians told us that lack of diagnostics was a source of frustration for them. There are a lot of patients that they couldn’t treat unless it was malaria or a small host of other diseases.
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Feb 23, 2024 | 
hms.harvard.edu | Claire Hendershot |Jason Flannick
At a glance:Research shows that type 2 diabetes in adolescents appears to arise from a mix of rare and common gene variants. The findings can pave the way toward more nuanced diagnosis and precision-targeted treatments for this form of the condition. The diabetes field has long classified the disorder into two distinct groups, type 1 and type 2. However, new genetics research focused on a form of type 2 diabetes that is becoming more common in adolescents suggests a more complicated picture.
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Feb 21, 2024 | 
broadinstitute.org | Claire Hendershot
Skip to main content About usThis is Broad Learn about our mission, history, and partner institutions. People Meet our members, staff scientists, fellows, leadership, and other Broadies. Join Broad Find out how to join the Broad as an employee or associate member. Contact us Find our contact information, directions to our buildings, and directory.
