Jason Flannick

Sep 14, 2024 | nature.com | Jacqueline S. Dron |Jason Flannick |Gina M. Peloso

AbstractInsulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological studies. To discover novel insulin resistance genes in the general population, we conducted genome-wide association studies in 382,129 individuals for triglyceride to HDL-cholesterol ratio (TG/HDL), a surrogate marker of insulin resistance calculable from commonly measured serum lipid profiles.

Feb 23, 2024 | hms.harvard.edu | Claire Hendershot |Jason Flannick

At a glance:Research shows that type 2 diabetes in adolescents appears to arise from a mix of rare and common gene variants. The findings can pave the way toward more nuanced diagnosis and precision-targeted treatments for this form of the condition. The diabetes field has long classified the disorder into two distinct groups, type 1 and type 2. However, new genetics research focused on a form of type 2 diabetes that is becoming more common in adolescents suggests a more complicated picture.

Jan 25, 2024 | nature.com | Soo Heon Kwak |Josep M. Mercader |Jose C. Florez |Jason Flannick

AbstractThe prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1, producing a growing public health concern1 that disproportionately affects minority groups2. The genetic basis of youth-onset T2D and its relationship to other forms of diabetes are unclear3.