Claire Lhuillier

Oct 16, 2024 | digitalcommons.library.tmc.edu | Nils-Petter Rudqvist |Maud Charpentier |Claire Lhuillier |Erik Wennerberg

Radiation therapy (RT) increases tumor response to CTLA-4 inhibition (CTLA4i) in mice and in some patients, yet deep responses are rare. To identify rational combinations of immunotherapy to improve responses we use models of triple negative breast cancer highly resistant to immunotherapy in female mice. We find that CTLA4i promotes the expansion of CD4+ T helper cells, whereas RT enhances T cell clonality and enriches for CD8+ T cells with an exhausted phenotype.

Aug 24, 2023 | nature.com | Nils-Petter Rudqvist |Maud Charpentier |Claire Lhuillier |Erik Wennerberg |Sheila Spada |Xi ZHOU | +2 more

AbstractRadiation therapy (RT) increases tumor response to CTLA-4 inhibition (CTLA4i) in mice and in some patients, yet deep responses are rare. To identify rational combinations of immunotherapy to improve responses we use models of triple negative breast cancer highly resistant to immunotherapy in female mice. We find that CTLA4i promotes the expansion of CD4+ T helper cells, whereas RT enhances T cell clonality and enriches for CD8+ T cells with an exhausted phenotype.