Sheila Spada

Aug 24, 2023 | nature.com | Nils-Petter Rudqvist |Maud Charpentier |Claire Lhuillier |Erik Wennerberg |Sheila Spada |Xi ZHOU | +2 more

AbstractRadiation therapy (RT) increases tumor response to CTLA-4 inhibition (CTLA4i) in mice and in some patients, yet deep responses are rare. To identify rational combinations of immunotherapy to improve responses we use models of triple negative breast cancer highly resistant to immunotherapy in female mice. We find that CTLA4i promotes the expansion of CD4+ T helper cells, whereas RT enhances T cell clonality and enriches for CD8+ T cells with an exhausted phenotype.

Mar 9, 2023 | frontiersin.org | Sheila Spada |Sanjay Pandey |Giuseppe Schepisi |Emine Kilic Bagir

IntroductionCancers of the kidney and renal pelvis are anticipated to occur in 79,000 individuals in the United States in 2022, the majority of these cases constituting renal cell carcinoma (RCC) (1). RCC is a diverse disease comprising multiple biologically distinct histological features. The most frequent histological type (representing 70%-80% of cases) is clear cell RCC (ccRCC), which is driven by alterations in the Von Hippel-Lindau (VHL) gene (2).

Mar 9, 2023 | frontiersin.org | Sheila Spada |Sanjay Pandey |Giuseppe Schepisi |Emine Kilic Bagir

IntroductionCancers of the kidney and renal pelvis are anticipated to occur in 79,000 individuals in the United States in 2022, the majority of these cases constituting renal cell carcinoma (RCC) (1). RCC is a diverse disease comprising multiple biologically distinct histological features. The most frequent histological type (representing 70%-80% of cases) is clear cell RCC (ccRCC), which is driven by alterations in the Von Hippel-Lindau (VHL) gene (2).