Claudia L. Satizabal

May 13, 2024 | digitalcommons.library.tmc.edu | Maria J. Knol |Raymond Poot |Tavia E. Evans |Claudia L. Satizabal

AbstractThe size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways.

Feb 22, 2023 | inkl.com | Claudia L. Satizabal

They say it is important to address obesity and begin healthy weight loss when people reach their 40s and 50s. Researchers analysed data from 5,619 people in the Framingham Heart Study – an ongoing study in America – and looked at 74 Alzheimer’s-related genes. They found 13 of the genes were associated with body mass index (BMI), while eight genes were associated with a second metric of obesity called waist-to-hip ratio.

Feb 9, 2023 | nature.com | Itziar de Rojas |Najada Stringa |Anna Zettergren |Rebecca Sims |Céline Bellenguez |Miguel Calero | +79 more

Author notesThese authors contributed equally: Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen. These authors jointly supervised this work: Jordi Clarimón, Mercè Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustín Ruiz.