Claudia L. Satizabal

May 13, 2024 | digitalcommons.library.tmc.edu | Maria J. Knol |Raymond Poot |Tavia E. Evans |Claudia L. Satizabal

AbstractThe size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways.