Claudio Mauro

Mar 29, 2024 | nature.com | Hannah Bradford |Joseph Ng |Deborah Dunn-Walters |David A. Isenberg |Adnan R. Khan |Claudio Mauro

AbstractMetabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (Breg) cell differentiation and function is unknown. Here we show that Breg cell differentiation, unlike non-Breg cells, relies on mitochondrial electron transport and homeostatic levels of reactive oxygen species (ROS).

Jan 23, 2024 | nature.com | Claudio Mauro

Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.