David A. Isenberg

Mar 29, 2024 | nature.com | Hannah Bradford |Joseph Ng |Deborah Dunn-Walters |David A. Isenberg |Adnan R. Khan |Claudio Mauro

AbstractMetabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (Breg) cell differentiation and function is unknown. Here we show that Breg cell differentiation, unlike non-Breg cells, relies on mitochondrial electron transport and homeostatic levels of reactive oxygen species (ROS).