Cody Elkins

Jan 10, 2025 | science.org | Rama K. Gurram |Cody Elkins |Marita Bosticardo |Peng Li

Editor’s summaryThe type I cytokine thymic stromal lymphopoietin (TSLP) is well known for its roles in regulating type 2 immunity and promoting allergic responses. Gurram et al. examined how TSLP acts directly on regulatory T cells (Tregs), which affects both phenotype and function. They observed that deletion of the TSLP receptor (TSLPR) from all T cells resulted in diminished type 2 responses after ovalbumin (OVA)–induced airway challenge.

Jan 10, 2025 | science.org | Rama K. Gurram |Cody Elkins |Marita Bosticardo |Kerry Dobbs

Editor’s summaryRecombination-activating gene 1 (RAG1) and RAG2 are required for V(D)J recombination, which directs mature B and T cell development and a fully functional adaptive immune system. Hypomorphic variants of the RAG genes in humans results in an array of immunodeficiencies, which all have distinct features for reasons not well understood. Bosticardo et al.

Dec 10, 2024 | cell.com | Cody Elkins |Chaoran Li

Get full text accessLog in, subscribe or purchase for full access. References1. Yu, W.-W. ∙ Barrett, J.N.P. ∙ Tong, J. ... Immune-mesenchymal interplay within tertiary lymphoid structures in the skin promotes autoimmune pathogenesis in Hidradenitis SuppurativaImmunity. 2024; 6:2827-2842.e52. Sabat, R. ∙ Jemec, G.B.E. ∙ Matusiak, Ł. ... Hidradenitis suppurativaNat. Rev. Dis. Primers. 2020; 6:183. Lowe, M.M. ∙ Naik, H.B. ∙ Clancy, S. ...

Apr 26, 2024 | onlinelibrary.wiley.com | Cody Elkins |Chaoran Li

CONFLICT OF INTEREST STATEMENT Authors have no competing interests to declare. REFERENCES 1, . What we talk about when we talk about fat. Cell. 2014; 156(1–2): 20-44. 2. Immunological goings-on in visceral adipose tissue. Cell Metab. 2013; 17(6): 851-859. 3. Foundations of immunometabolism and implications for metabolic health and disease. Immunity. 2017; 47(3): 406-420. 4, , . An integrated view of immunometabolism. Cell. 2018; 172(1–2): 22-40. 5, , , , .