Marita Bosticardo

Jan 10, 2025 | science.org | Rama K. Gurram |Cody Elkins |Marita Bosticardo |Peng Li

Editor’s summaryThe type I cytokine thymic stromal lymphopoietin (TSLP) is well known for its roles in regulating type 2 immunity and promoting allergic responses. Gurram et al. examined how TSLP acts directly on regulatory T cells (Tregs), which affects both phenotype and function. They observed that deletion of the TSLP receptor (TSLPR) from all T cells resulted in diminished type 2 responses after ovalbumin (OVA)–induced airway challenge.

Jan 10, 2025 | science.org | Rama K. Gurram |Cody Elkins |Marita Bosticardo |Kerry Dobbs

Editor’s summaryRecombination-activating gene 1 (RAG1) and RAG2 are required for V(D)J recombination, which directs mature B and T cell development and a fully functional adaptive immune system. Hypomorphic variants of the RAG genes in humans results in an array of immunodeficiencies, which all have distinct features for reasons not well understood. Bosticardo et al.