Colleen M. Fitzpatrick

Jul 5, 2023 | biorxiv.org | Stephanie Schultz |Lei Liu |Aaron Schultz |Colleen M. Fitzpatrick

AbstractBackground: The balance between production, clearance, and toxicity of Aβ peptides is central to Alzheimer's disease (AD) pathobiology. Though highly variable in terms of age at symptom onset (AAO), hundreds of variants in PSEN1 cause autosomal dominant forms of AD (ADAD) with nearly complete penetrance.