Computational Neuroimmunology

Aug 15, 2024 | academic.oup.com | Computational Neuroimmunology |de Jager |Neurodegenerative Diseases

Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with evidence for substantial heritability [1]. More than 70 AD susceptibility loci have been identified by human genome-wide association studies (GWAS), with hopes for new therapies targeting the proximate disease causes [2–4]. However, the translational path from GWAS faces two overarching challenges.

Aug 1, 2023 | academic.oup.com | Computational Neuroimmunology

Droplet-based single-cell RNA sequencing (scRNA-seq) is widely used in biomedical research for interrogating the transcriptomes of single cells on a large scale. Pooling and processing cells from different samples together can reduce costs and batch effects. To pool cells, they are often first labeled with hashtag oligonucleotides (HTOs).