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Jan 24, 2025 | 
link.springer.com | Binhai Campus |Neurodegenerative Diseases
AbstractPeripheral neuropathy (PN) identified as a significant contributor to disability in Spinocerebellar ataxia type 3 (SCA3) patients. This study seeks to assess the utility of current perception threshold (CPT) measurements in evaluating PN in individuals with SCA3 and aims to identify factors influencing CPT values in SCA3 and ascertain whether these values correlate with the severity of ataxia.
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Jan 6, 2025 | 
molecularneurodegeneration.biomedcentral.com | Neurodegenerative Diseases
It is unknown whether a cellular regulatory machinery might control seeding by tau, especially within the initial hours of cell entry. To identify factors that participate in tau seed amplification within 5 h of exposure, we used proximity labeling to identify VCP, which has previously been genetically and biochemically linked to chronic tau aggregation [17, 18, 19], and to inhibition of α-synuclein and TDP-43 seeding [20].
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Nov 21, 2024 | 
academic.oup.com | Rovira i Virgili |Neurodegenerative Diseases |San Antonio |Jose Luis
Substantial evidence supports the relationship between peripheral insulin resistance (IR) and the development of Alzheimer’s disease (AD)-dementia. However, the mechanisms explaining these associations are only partly understood. We aimed to identify a metabolic signature of IR associated with the progression from mild cognitive impairment (MCI) to AD-dementia. This is a case-control study on 400 MCI subjects, free of type 2 diabetes, within the ACE cohort, including individuals ATN+ and ATN-.
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Oct 28, 2024 | 
academic.oup.com | Neurodegenerative Diseases |Cheeloo College
Limb-girdle muscular dystrophy R7 is a rare genetic disease caused by homozygous or compound heterozygous variants in the titin-cap (TCAP) gene that results in the absence of the protein telethonin. The primary pathological features of limb-girdle muscular dystrophy R7 are fiber size variation, nuclear centralization, and abnormal mitochondrial distribution. The mechanisms underlying this disease are unclear, and there is currently no specific treatment for limb-girdle muscular dystrophy R7.
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Sep 4, 2024 | 
molecularneurodegeneration.biomedcentral.com | Shenzhen Shenzhen |Neurodegenerative Diseases
Experimental designThis translational study used preclinical (n = 224) and human (n = 59) TSPO-PET imaging data, which were consistently analyzed with ICCs for assessment of regional synchronicity of the tracer signal (Fig. 1A and B). Mice with microglia depletion via colony-stimulating factor 1 receptor (CSF1R) inhibition using PLX5622 were analyzed in contrast to age-matched placebo controls as a proof-of-concept experiment.
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Aug 30, 2024 | 
jneuroinflammation.biomedcentral.com | Neurodegenerative Diseases
To explore the expression level change of LILRB4 in murine models post-MCAO, C57BL/6J WT mice were randomly allocated into a sham group and a MCAO group. In addition, to investigate the influence and underlying mechanisms of LILRB4 on brain injury and neurological function in murine models post-MCAO, LILRB4-KO, LILRB4-TG and their littermate control transgenic floxed mice known as Control-KO and Control-TG were randomly distributed into a Sham group and a MCAO group.
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Aug 15, 2024 | 
academic.oup.com | Computational Neuroimmunology |de Jager |Neurodegenerative Diseases
Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with evidence for substantial heritability [1]. More than 70 AD susceptibility loci have been identified by human genome-wide association studies (GWAS), with hopes for new therapies targeting the proximate disease causes [2–4]. However, the translational path from GWAS faces two overarching challenges.
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Aug 9, 2024 | 
einpresswire.com | Bone Diseases |Neurodegenerative Diseases
BURLINGAME, CALIFORNIA, UNITED STATES, August 9, 2024 / EINPresswire.com/ -- The latest market intelligence report published by CMI with the title "Global Ambulatory Infusion Center Market 2024, Growth Opportunities, and Forecast" provides actionable insights on Medical Devices industry. The report provides demand analysis, industry insights, competitive intelligence, and customer database.
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Aug 1, 2024 | 
bmcgenomics.biomedcentral.com | Neurodegenerative Diseases |Cheeloo College
Correction: HiFi long-read amplicon sequencing for full-spectrum variants of human mtDNA Correction Open access Published: 30 July 2024 BMC Genomics volume 25, Article number: 745 (2024) Cite this article The Original Article was published on 31 May 2024 Correction: BMC Genomics 25, 538 (2024)In this article, an older version of Figure 5 was submitted for publication. The correct and incorrect version of Fig. 5 is given below.
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Jul 1, 2024 | 
karger.com | Kyung Hee |Neurodegenerative Diseases |Anglia Ruskin
Keywords:
Allergic diseases,
Soda drinks,
Fast food,
South Korea,
Adolescents
Allergic diseases are currently emerging as a notable health problem that is increasing among adolescents worldwide. They occur more often in adolescents than chronic diseases [1, 2] and have a significant impact on their health and quality of life [3, 4]. The factors causing allergic diseases include both innate and acquired elements [5].
