Congsheng Zhang

Aug 16, 2023 | mdpi.com | Yiru Zhu |Congsheng Zhang |Pinzhi Sun |Shangrui Fan

3. Results 3.1. Formulation Development for “Jifang E” Sustained-Release InjectionPoloxamer 407 was chosen as a sustained-release excipient because it is a substance with amphiphilic properties of polyethylene oxide (PEO) and polypropylene oxide (PPO), which can be gelled below physiological temperature at concentrations of 15% to 30% (w/v), and the gelling temperature gradually decreases as the concentration increases (Figure 1A).