Connie Myers

Nov 14, 2024 | biorxiv.org | Yu Liu |Connie Myers |Ala Morshedian |Yohey Ogawa

AbstractThe identification of homologous cell types across species represents a crucial step in understanding cell type evolution. The retina is particularly amenable to comparative analysis because the basic morphology, connectivity, and function of its six major cell classes have remained largely invariant since the earliest stages of vertebrate evolution.

Jan 16, 2024 | journals.plos.org | Kaiser J Loell |Ryan Friedman |Connie Myers |Joseph C. Corbo

Loading metrics Open Access Peer-reviewedResearch Article Citation: Loell KJ, Friedman RZ, Myers CA, Corbo JC, Cohen BA, White MA (2024) Transcription factor interactions explain the context-dependent activity of CRX binding sites. PLoS Comput Biol 20(1): e1011802. https://doi.org/10.1371/journal.pcbi.1011802Editor: Jie Liu, University of Michigan, UNITED STATESReceived: March 6, 2023; Accepted: January 6, 2024; Published: January 16, 2024Copyright: © 2024 Loell et al.

Aug 22, 2023 | biorxiv.org | Ryan Friedman |Avinash Ramu |Sara Lichtarge |Connie Myers

ABSTRACTCis-regulatory elements (CREs) direct gene expression in health and disease, and models that can accurately predict their activities from DNA sequences are crucial for biomedicine. Deep learning represents one emerging strategy to model the regulatory grammar that relates CRE sequence to function. However, these models require training data on a scale that exceeds the number of CREs in the genome.