Ryan Friedman

Sep 5, 2024 | gis.stackexchange.com | Ryan Friedman

I have the following C++ code, where I create a line string in the geographic coordinate system. Then, I want to check the distance between the line segment and a point on the line.

Jan 16, 2024 | journals.plos.org | Kaiser J Loell |Ryan Friedman |Connie Myers |Joseph C. Corbo

Loading metrics Open Access Peer-reviewedResearch Article Citation: Loell KJ, Friedman RZ, Myers CA, Corbo JC, Cohen BA, White MA (2024) Transcription factor interactions explain the context-dependent activity of CRX binding sites. PLoS Comput Biol 20(1): e1011802. https://doi.org/10.1371/journal.pcbi.1011802Editor: Jie Liu, University of Michigan, UNITED STATESReceived: March 6, 2023; Accepted: January 6, 2024; Published: January 16, 2024Copyright: © 2024 Loell et al.

Nov 12, 2023 | nature.com | Ryan Friedman |Simona Sarafinovska |Joon-Yong An |Stephan Sanders |Barak A. Cohen

AbstractThe function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment.

Aug 22, 2023 | biorxiv.org | Ryan Friedman |Avinash Ramu |Sara Lichtarge |Connie Myers

ABSTRACTCis-regulatory elements (CREs) direct gene expression in health and disease, and models that can accurately predict their activities from DNA sequences are crucial for biomedicine. Deep learning represents one emerging strategy to model the regulatory grammar that relates CRE sequence to function. However, these models require training data on a scale that exceeds the number of CREs in the genome.

Jan 28, 2023 | newsbreak.com | Ryan Friedman

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