Constantinos Koshiaris

Jul 27, 2023 | bjgp.org | Constantinos Koshiaris |Lucinda Archer |Sarah Lay-Flurrie |Richard Riley

blood pressure drug-related side effects and adverse reactions electronic health records epidemiology primary health care vascular diseases INTRODUCTION Blood pressure lowering (antihypertensive) medications are one of the most commonly prescribed medications in older people.1 They are highly effective at reducing the risk of cardiovascular disease (CVD) and mortality;2 however, they are also associated with adverse events, including acute kidney injury (AKI), electrolyte abnormalities,...

May 3, 2023 | bjgp.org | Constantinos Koshiaris |Lucinda Archer |Sarah Lay-Flurrie |Richard Riley

External validationThe external validation was conducted independently by researchers at a different institution.

Apr 19, 2023 | journals.plos.org | James Sheppard |Constantinos Koshiaris |Richard Stevens |Sarah Lay-Flurrie

Strengths and limitationsTo our knowledge, this was the largest population-based analysis of serious adverse events associated with antihypertensive therapy conducted to date [15], and the first to examine how these associations vary by age and frailty. Data were taken from 2 databases of electronic health records, covering more than half the population in England, and representative on the basis of age, ethnicity, and deprivation [12,13].