Cornelia Fritsch

Aug 17, 2024 | nature.com | Hongsu Wang |Kelvin Yeung |Carolyn Morrison |Cornelia Fritsch |Simon G. Sprecher |Graeme Mardon | +1 more

AbstractThe integration of extrinsic signaling with cell-intrinsic transcription factors can direct progenitor cells to differentiate into distinct cell fates. In the developing Drosophila eye, differentiation of photoreceptors R1–R7 requires EGFR signaling mediated by the transcription factor Pointed, and our single-cell RNA-Seq analysis shows that the same photoreceptors require the eye-specific transcription factor Glass.

Jun 2, 2024 | biorxiv.org | Jenifer C. Kaldun |Cornelia Fritsch |Simon G. Sprecher |Nikita Komarov

AbstractDopamine is a crucial neuromodulator, which is involved in many brain processes, including learning and the formation of memories. Dopamine acts through multiple receptors and controls an intricate signaling network to regulate different tasks. While the diverse functions of dopamine are intensely studied, the interplay and role of the distinct dopamine receptors to regulate different processes is less well understood.