Kelvin Yeung

2 months ago | digitalcommons.library.tmc.edu | Kelvin Yeung |Yumei Li |Rui Chen |Graeme Mardon

KeywordsAnimals, Larva, Eye, Single-Cell Analysis, Gene Expression Profiling, Transcriptome, Gene Expression Regulation, Developmental, Drosophila, Drosophila melanogaster, Sequence Analysis, RNA, Drosophila eye, Single cell genomics, Eye disc single cell RNA, Drosophila single cell omicsAbstractThe Drosophila eye has been an important model to understand principles of differentiation, proliferation, apoptosis and tissue morphogenesis.

2 months ago | digitalcommons.library.tmc.edu | Hongsu Wang |Kelvin Yeung |Carolyn Morrison |Antonia Terrizzano

Nature Communications 10.1038/s41467-024-51429-z Post-print yes Animals, Drosophila Proteins, Transcription Factors, ErbB Receptors, Drosophila melanogaster, Signal Transduction, Gene Expression Regulation, Developmental, Neurons, DNA-Binding Proteins, Cell Differentiation, Photoreceptor Cells, Invertebrate, Eye Proteins, Imaginal Discs, Nerve Tissue Proteins, Proto-Oncogene Proteins, Receptors, Invertebrate Peptide, Differentiation, Transcriptomics, Developmental neurogenesis,...

Aug 17, 2024 | nature.com | Hongsu Wang |Kelvin Yeung |Carolyn Morrison |Cornelia Fritsch |Simon G. Sprecher |Graeme Mardon | +1 more

AbstractThe integration of extrinsic signaling with cell-intrinsic transcription factors can direct progenitor cells to differentiate into distinct cell fates. In the developing Drosophila eye, differentiation of photoreceptors R1–R7 requires EGFR signaling mediated by the transcription factor Pointed, and our single-cell RNA-Seq analysis shows that the same photoreceptors require the eye-specific transcription factor Glass.

Mar 10, 2024 | biorxiv.org | Kelvin Yeung |Yumei Li |Rui Chen |Graeme Mardon

AbstractThe Drosophila eye has been an important model to understand principles of differentiation, proliferation, apoptosis and tissue morphogenesis. However, a single cell RNA sequence resource that captures gene expression dynamics from the initiation of differentiation to the specification of different cell types in the larval eye disc is lacking. Here, we report transcriptomic data from 13,000 cells that cover six developmental stages of the larval eye.