Courtney Carlson

Jun 11, 2024 | biorxiv.org | Courtney Carlson |Theresa B Loveless |Patrick Kelly |Marija Milisavljevic

AbstractTerminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase capable of template-independent extension of DNA with random nucleotides. TdT's de novo DNA synthesis ability has found utility in DNA recording, DNA data storage, oligonucleotide synthesis, and nucleic acid labeling, but TdT's intrinsic nucleotide biases limit its versatility in such applications.