Craig B. Wilen

Mar 8, 2024 | jbc.org | Aaron Embry |John G. Doench |Nicholas Heaton |Craig B. Wilen

AbstractThe innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape we conducted a gain of function, genome-wide CRISPR activation screen with influenza A virus. We identified both appreciated and novel antiviral genes, including JADE3 a protein involved in directing the histone acetyltransferase HBO1 complex to modify chromatin and regulate transcription.