Aaron Embry

Nov 4, 2024 | biorxiv.org | Aaron Embry |Emily A. Rex |Neal M. Alto |David Schad

AbstractArboviruses are a group of arthropod transmitted viruses that pose a significant threat to public health. Identifying host factors that inhibit arbovirus infection is critical for the development of strategies to prevent or treat these infections. Previously, we showed that bacterial effector proteins can be used as molecular tools to identify host immunity factors in insect cells that restrict arbovirus replication (Embry et al., 2024).

Oct 8, 2024 | journals.plos.org | Aaron Embry |Heather Knight |Alexa A. Krause |Nicholas K. Reimold

Loading metrics Open Access Peer-reviewedResearch Article Citation: Krause AA, Reimold NK, Embry AE, Knight HL, Jacobs CJ, Boan AD, et al. (2024) Effect of mediolateral leg perturbations on walking balance in people with chronic stroke: A randomized controlled trial. PLoS ONE 19(10): e0311727. https://doi.org/10.1371/journal.pone.0311727Editor: Ryan T.

Aug 22, 2024 | biorxiv.org | Dahee Seo |Aaron Embry |Rozanne Arulanandam |Jean-Simon Diallo

AbstractWe recently identified the FACT-ETS-1 Antiviral Response (FEAR) pathway as an interferon-independent innate immune response that restricts DNA virus replication and is countered by poxvirus-encoded A51R proteins (Rex et al., 2024, Nature Microbiology). The human FEAR pathway is mediated by the FACT complex, consisting of hSpt16 and SSRP1 subunits, that remodels chromatin to activate expression of the antiviral transcription factor, ETS-1.

May 16, 2024 | journals.plos.org | Aaron Embry |Nina S. Baggett |David Heisler |Addison White |PLOS Pathogens

DiscussionOur study illustrates the utility of using abortive virus infections as a screening tool to identify IEPs and the host immunity factors they target. From this work, we identify a variety of bacterially-encoded proteins capable of rescuing individual arbovirus infections, as well as six that are capable of rescuing all four viruses screened.

May 16, 2024 | journals.plos.org | Aaron Embry |Nina S. Baggett |David Heisler |Addison White |PLOS Pathogens

DiscussionOur study illustrates the utility of using abortive virus infections as a screening tool to identify IEPs and the host immunity factors they target. From this work, we identify a variety of bacterially-encoded proteins capable of rescuing individual arbovirus infections, as well as six that are capable of rescuing all four viruses screened.