Curtis Cai

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CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies - Nature Communications

Nov 27, 2023 | nature.com | Curtis Cai |Mandeep Singh |Ira W. Deveson |James Ferguson |Timothy Amos |Robert Balderas | +3 more

AbstractChimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of functional CAR+ T cells, such as product composition, patients’ lymphodepletion, and immune reconstitution, are not well understood.

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