Ira W. Deveson

Mar 3, 2024 | nature.com | Skye D. Fissette |Deniz Kaya |Jillian Hammond |Hasindu Gamaarachchi |Ira W. Deveson |Robert Klose | +2 more

AbstractDNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate genomes, yet the developmental dynamics in which 5mC patterns are established vary across species. While mammals undergo two rounds of global 5mC erasure, teleosts, for example, exhibit localized maternal-to-paternal 5mC remodeling.

Nov 27, 2023 | nature.com | Curtis Cai |Mandeep Singh |Ira W. Deveson |James Ferguson |Timothy Amos |Robert Balderas | +3 more

AbstractChimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of functional CAR+ T cells, such as product composition, patients’ lymphodepletion, and immune reconstitution, are not well understood.