Dag Sehlin

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Articles

Targeting pathological alpha-synuclein : Protein engineering towards improved antibody-based therapeutics and their delivery to the brain

Oct 11, 2024 | avhandlingar.se | Greta Hultqvist |Dag Sehlin |Anna Erlandsson |Daniel Otzen

Nyckelord: NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease PD ; alpha-synuclein αSyn ; beta-hairpin; protein drugs; multivalent antibodies; blood-brain barrier BBB ; transferrin receptor TfR ; Sammanfattning: The aggregation of alpha-synuclein (αSyn) into oligomers and fibrils is central to the disease progression of Parkinson’s disease and related pathologies, where αSyn aggregates spread between neurons and cause...

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