Daniel Otzen

Oct 11, 2024 | avhandlingar.se | Greta Hultqvist |Dag Sehlin |Anna Erlandsson |Daniel Otzen

Nyckelord: NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease PD ; alpha-synuclein αSyn ; beta-hairpin; protein drugs; multivalent antibodies; blood-brain barrier BBB ; transferrin receptor TfR ; Sammanfattning: The aggregation of alpha-synuclein (αSyn) into oligomers and fibrils is central to the disease progression of Parkinson’s disease and related pathologies, where αSyn aggregates spread between neurons and cause...

May 2, 2024 | onlinelibrary.wiley.com | Samuel Peña-Díaz |William Olsen |Huabing Wang |Daniel Otzen

Daniel E. Otzen Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C, DK - 8000 Denmark Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, Aarhus C, 8000 DenmarkSearch for more papers by this author

Feb 2, 2024 | onlinelibrary.wiley.com | Samuel Peña-Díaz |William Olsen |Huabing Wang |Daniel Otzen

1 Introduction: From Exploitation to Coexistence The subjugation of Nature has always been a driving force of human innovation. In prehistoric times, humankind domesticated animals and grew crops, facilitating a sedentary existence with a (reasonably) stable food supply. In the Industrial Revolution, metal was wrought into machines to automate processes ranging from the butchering of animals to the production of clothes.

Oct 22, 2023 | biorxiv.org | Farhang Aliakbari |Daniel Otzen |Kimia Marzookian |Hamdam Hourfar

AbstractThe blood-brain barrier (BBB) is a highly developed endothelial microvessel network extended to almost all parts of the central nervous system (CNS) that tightly seals cell-to-cell contacts and plays a critical role in maintaining CNS homeostasis. It also protects neurons from factors present in systemic circulation and prevents pathogens from entering the brain. Conversely, BBB disruption can initiate multiple pathways of nerve damage.

Sep 18, 2023 | nature.com | Steven J. Roeters |Kris Strunge |Yuge Zhang |Mingdong Dong |Daniel Otzen |Birgit Schiøtt | +2 more

AbstractThe amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail. Here, we report interface-specific vibrational sum-frequency generation (VSFG) experiments that reveal how monomeric αS binds to an anionic lipid interface over a large range of αS-lipid ratios.