Daisuke Okuzaki

Oct 23, 2024 | nature.com | Ritsuko Nakai |Takafumi Yokota |Yoshiaki Yasumizu |Daisuke Okuzaki |Junko Yoshida |Kyoji Horie | +1 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-49252-7, published online 25 June 2024The original version of this Article contained an error in the schematic representation of the AHED protein in Fig. 2C. This error has been corrected in both the PDF and HTML versions of the Article.

Jun 25, 2024 | nature.com | Takafumi Yokota |Yoshiaki Yasumizu |Daisuke Okuzaki |Junko Yoshida |Kyoji Horie |Shigetoshi Sano | +1 more

AbstractThe development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the biological function of many genes remains elusive and unknown functional genes are likely to remain to be uncovered. Here, we report a previously uncharacterised gene in haematopoiesis, identified by screening mutant embryonic stem cells. The gene, ‘attenuated haematopoietic development (Ahed)’, encodes a nuclear protein.

Apr 24, 2023 | nature.com | Yuya Shirai |Yusuke Takeshima |Shuhei Sakakibara |Yuta Yamaguchi |James B. Wing |Daisuke Okuzaki | +1 more

AbstractMechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono).

Mar 3, 2023 | nature.com | Daisuke Okuzaki |Hidekazu Takahashi |Tsunekazu Mizushima

Study design and patientsThis study evaluated 126 patients with CRC who underwent surgical resection from 2012 to 2013 for immunohistochemistry staining and overall survival (OS) and recurrence-free survival (RFS) rate. Freshly resected CRC tissues and adjacent normal tissues were obtained immediately after surgical resection in 2020.