Dan L. Longo

2 months ago | jamanetwork.com | Mark Roschewski |Dan L. Longo |James Armitage

Circulating Tumor DNA as Measurable Residual Disease in Aggressive B-Cell Lymphoma: A Narrative Review Abstract Importance  Achieving remission is the first step toward a cure in treating aggressive B-cell lymphomas. Radiographic imaging, such as fluorodeoxyglucose–positron emission tomography/computed tomography scans are the current standard to define remission at the end of therapy but lack specificity for lymphoma and cannot detect disease at the molecular level.

Apr 10, 2024 | nejm.org | C. Corey Hardin |Dan L. Longo |Julie R. Ingelfinger

Published April 10, 2024 N Engl J Med 2024;390:1324-1325 DOI: 10.1056/NEJMe2313282 For permission requests, please contact NEJM Reprints at [email protected] Worldwide, 11 million deaths per year are attributed to suboptimal diets, including those with high sodium, low whole-grain, and low fruit content.1 Dietary factors contribute to hypertension, obesity, heart disease, stroke, type 2 diabetes mellitus, and cancers, especially gastric and colorectal cancers.2-4 Up to one in four Americans...

Oct 4, 2023 | nejm.org | Dan L. Longo

October 5, 2023N Engl J Med 2023; 389:1310-1319 DOI: 10.1056/NEJMra2304431Dan L. Longo, M.D., Editor Stem cells can renew themselves without differentiating. Aging, inflammation, and environmental exposures may drive phenotypic changes in tissue stem cells that cause them to become cancer stem cells. Funding and Disclosures Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Sep 6, 2023 | nejm.org | Dan L. Longo |Elizabeth G. Phimister

This article is available to subscribers. Subscribe now. Already have an account? Sign in EditorialScience behind the StudyFree PreviewList of authors. September 7, 2023N Engl J Med 2023; 389:953-957 DOI: 10.1056/NEJMe2304744Elizabeth G. Phimister, Ph.D., Editor This editorial describes the science behind a study that used base-edited CAR T cells to treat patients with T-cell lymphoblastic leukemia.

Jul 12, 2023 | nejm.org | Thomas Smith |Eric Wang |Charles L. Loprinzi |Dan L. Longo

This article is available to subscribers. Subscribe now. Already have an account? Sign in Review ArticleList of authors. Thomas J. Smith, M.D., Eric J. Wang, M.D., and Charles L. Loprinzi, M.D. Article Figures/Media Metrics Related ArticlesThe authors discuss two forms of cutaneous electroanalgesia for pain relief — transcutaneous electrical nerve stimulation and scrambler therapy — addressing technology, safety, and results from randomized trials.