Daniel A. Mordes

Sep 12, 2024 | nature.com | Cory M. Nadel |Aye C. Thwin |Matthew Callahan |Daniel R. Southworth |Daniel A. Mordes |Charles S. Craik | +1 more

AbstractMicrotubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these PTMs contribute to tau’s accumulation or what mechanisms might be involved.

Sep 11, 2024 | flipboard.com | Cory M. Nadel |Saugat Pokhrel |Kristin Wucherer |Abby Oehler |Aye C. Thwin |Matthew Callahan | +5 more

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIPMicrotubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, …