Charles S. Craik

Sep 12, 2024 | nature.com | Cory M. Nadel |Aye C. Thwin |Matthew Callahan |Daniel R. Southworth |Daniel A. Mordes |Charles S. Craik | +1 more

AbstractMicrotubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these PTMs contribute to tau’s accumulation or what mechanisms might be involved.

Sep 11, 2024 | flipboard.com | Cory M. Nadel |Saugat Pokhrel |Kristin Wucherer |Abby Oehler |Aye C. Thwin |Matthew Callahan | +5 more

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIPMicrotubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, …

Jan 12, 2024 | nature.com | Ruchika Bajaj |Ilan E. Chemmama |Meghna Gupta |Andrej Sali |Yifan Cheng |Charles S. Craik

AbstractMultidrug resistance protein 4 (MRP4) is a broadly expressed ATP-binding cassette transporter that is unique among the MRP subfamily for transporting prostanoids, a group of signaling molecules derived from unsaturated fatty acids. To better understand the basis of the substrate selectivity of MRP4, we used cryogenic-electron microscopy to determine six structures of nanodisc-reconstituted MRP4 at various stages throughout its transport cycle.