Daniel C. Gibbons

Jun 13, 2023 | onlinelibrary.wiley.com | John Tazare |Daniel C. Gibbons |GSK London |Marleen Bokern

Abstract Purpose Prevalent new user (PNU) designs extend the active comparator new user design by allowing for the inclusion of initiators of the study drug who were previously on a comparator treatment. We performed a literature review summarising current practice. Methods PubMed was searched for studies applying the PNU design since its proposal in 2017. The review focused on three components. Firstly, we extracted information on the overall study design, including the database used.