Daniel Horn-Ghetko

Apr 11, 2024 | nature.com | Daniel Horn-Ghetko |Jiale Du |J. Rajan Prabu |Matthias Mann |Yue Xiong |Elias M. Bruss

AbstractUbiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, ‘cullin–RING’ and ‘RBR’, are individually found in several hundred human E3 ligases, and collaborate with E2 enzymes to catalyze ubiquitylation. However, the vertebrate-specific CUL9 complex with RBX1 (also called ROC1), of interest due to its tumor suppressive interaction with TP53, uniquely encompasses both cullin–RING and RBR domains.