Daniel Phillips

Oct 3, 2024 | biorxiv.org | David Garcia |John Davies |Charles Davidson |Daniel Phillips

AbstractCell-free expression systems maintain core cellular processes without intact cells and offer attractive properties as point-of-need biosensors. The ability to lyophilize, store, and use on demand makes these sensors usable in the field, and the lack of membranes means there are no analyte transport issues and new sensors can be deployed by simply adding a different DNA molecule. The lack of membranes also enables high-throughput screening of sensor designs and reaction optimizations.