Daniel T. Montoro

Sep 20, 2023 | nature.com | Feng Yuan |Grace Gasser |Daniel T. Montoro |Kristen Wells |David Dick |Hui Min Leung | +7 more

AbstractSpeciation leads to adaptive changes in organ cellular physiology and creates challenges for studying rare cell-type functions that diverge between humans and mice. Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmonary ionocytes exist throughout the cartilaginous airways of humans1,2, but limited presence and divergent biology in the proximal trachea of mice has prevented the use of traditional transgenic models to elucidate ionocyte functions in the airway.