Kristen Wells

Nov 25, 2023 | nature.com | Kristen Wells |Aliya F. Spigelman |Xiong Liu |Yong-Kyung Kim

AbstractInsulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly fine-tune secretion in response to changing environmental conditions is not well characterized. Recent studies have determined that dysregulation of RNA-binding proteins (RBPs) and aberrant mRNA splicing occurs at the onset of diabetes.

Sep 20, 2023 | nature.com | Feng Yuan |Grace Gasser |Daniel T. Montoro |Kristen Wells |David Dick |Hui Min Leung | +7 more

AbstractSpeciation leads to adaptive changes in organ cellular physiology and creates challenges for studying rare cell-type functions that diverge between humans and mice. Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmonary ionocytes exist throughout the cartilaginous airways of humans1,2, but limited presence and divergent biology in the proximal trachea of mice has prevented the use of traditional transgenic models to elucidate ionocyte functions in the airway.