Daniele Antermite

Dec 12, 2023 | nature.com | Daniele Antermite |Stig D. Friis |Johan Johansson |Okky Dwichandra Putra |Lutz Ackermann

AbstractPROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules emerging as a powerful modality in drug discovery, with the potential to address outstanding medical challenges. However, the synthetic feasibility of PROTACs, and the empiric and complex nature of their structure-activity relationships continue to present formidable limitations. As such, modular and reliable approaches to streamline the synthesis of these derivatives are highly desirable.